advances analyse analysed analyses analysing analysis analyze analyzes analyzed analyzing assess assessed assesses assessing assessment assessments benefit based benefits change changed changes changing characteristic characteristics characterize characterized characterizes characterizing clinical cluster combine combined combines combining comorbid comorbidity compare compared compares comparing comparison control controlled controlling controls design designed designing effect effective effectiveness effects efficacy feasible feasibility follow followed following follows group groups impact intervention interventions longitudinal moderate moderated moderates moderating moderator moderators outcome outcomes patient patients people pilot practice predict predicted predicting predictor predictors predicts preliminary primary protocol quality random randomise randomised randomising randomize randomized randomizing rationale reduce reduced reduces reducing related report reported reporting reports response responses result resulted resulting results review studied studies study studying systematic treat treated treating treatment treatments treats trial trials versus